An Activation Marker Finds a Function
نویسندگان
چکیده
منابع مشابه
Cajal body finds its function
he Cajal body (CB, formerly coiled body) is a prominent nuclear structure, yet its function remains obscure. Now, speculate that the CB is where small nuclear RNAs go for modification. Last year, Kiss's team identified a small guide RNA, U85, that directs both 2'-O-methylation and pseudouridylation of the spliceosomal component U5 snRNA. This year, they've identified six more RNAs, Novel guide ...
متن کاملEast meets West: an herbal tea finds a receptor.
Jaundice, which is caused by accumulation of bilirubin, is extremely common in newborn infants. Phototherapy is an effective treatment, but a drug therapy would also be desirable. A Chinese herbal remedy for jaundice called Yin Zhi Huang is now shown to activate a liver receptor that enhances the clearance of bilirubin (see the related article beginning on page 137). This discovery could lead t...
متن کاملAn "orphan" finds a home in NSC regulation.
Small molecules that can alter stem cell fate are of immense biological and therapeutic values. In this issue of Chemistry & Biology, Saxe and colleagues report a chemical genetic screen that identified an orphan ligand, P-Ser, which can modulate neural stem/progenitor cell fate.
متن کاملAn orphan GPCR finds a home in the heart.
G PROTEIN-COUPLED RECEPTORS (GPCRs) are the largest and most successful targets for pharmacotherapy to date, particularly in the area of cardiovascular disease. These receptors are at the forefront of current drug discovery efforts (7). GPCRs also form the largest family of transmembrane receptors, with nearly 800 GPCR loci (12, 18), of which several hundred are categorized as orphan GPCRs. The...
متن کاملMammalian Dicer finds a partner
RNA interference (RNAi) is a complex process that uses small RNAs of 21–23 nucleotides to guide sequence-specific silencing of genetic information at both the transcriptional and posttranscriptional levels. There are two main post-transcriptional gene-silencing pathways in metazoans: the microRNA (miRNA)mediated inhibition of translation and the small interfering RNA (siRNA)-mediated targeted d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunity
سال: 2010
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2010.01.003